Tottenham’s Premier League season begins on Saturday with a London derby against Brentford.
The north London club could be without as many as 13 players for the encounter.
Manager Roberto De Zerbi faces significant selection problems heading into the new campaign.
Tottenham finished 17th in the league for the second consecutive season and De Zerbi has attempted to strengthen the squad through extensive summer recruitment.
However, the availability crisis appears set to complicate the opening match of the term.
De Zerbi confirmed on Friday that defender Micky van de Ven and full-back Pedro Porro have been excluded from Saturday’s squad.
The Italian stated that James Maddison, Dominic Solanke, Destiny Udogie and Mateus Fernandes are all included in his plans.
Midfielder Pape Sarr has not made the list due to a hamstring problem that developed two days ago.
Regarding Van de Ven, De Zerbi noted that the defender trained with the squad on Friday and is progressing well.
The centre-back continues his recovery from a anterior cruciate ligament injury sustained last season.
The manager emphasised the importance of careful player management when individuals are dealing with physical issues, stating that caution must be exercised and risks avoided.
Brentford manager said on the subject of his own injured player that the individual is several weeks away from returning following an anterior cruciate ligament problem.
The player has been training with the group for several weeks, occasionally in modified sessions and sometimes fully participating.
Progress has been positive in recent weeks.
Another Brentford player is managing a groin complaint and requires additional rest as the club monitors the situation accordingly.